Category: Biology

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Pancreas – Hermit of the Abdomen

Pancreas – Hermit of the Abdomen

Ashley Davidoff MD

O’ Dear pancreas

You have been called the hermit of the abdomen
By whom I do not know
But in your dark and hidden way, you have
spoken without a word
from the gurgling depths of the abdomen
Yes – you have earned this lonely title
and a coin should be tossed
to the person who coined the phrase


 

But it took a long time to understand who this hermit was – and what he was doing in the darkness of the abdomen

From the day of antiquity
You have been looked upon by many
Herophilus, the father of anatomy had the first incisive insights into you
As he was one of very few who had the guts to explore the guts in open fashion

Aristotle at the same time seemed to have known something about you
But then you lay unharmed and unexplored for almost 500 years
Until Rufus mistook you for a piece of meat –
You must have laughed at the “pan kreas” thing
How wrong he was – you evasive little trickster

And then the Talmud – always seeming to be right
Thought you were the finger of the liver –
Little did they know how independant you were

While Vesalius was up to your “hide and seek” game
The magical eyes of da Vinci missed you completely
Even though he saw the serpiginous splenic artery snake right above you

Your ducts seemed to have intrigued the next generation, Wharton, Wirsung, and de Graaf
As you sustained the pain of the quill penetrating your inner gut
(I forget you were already dead but it must of hurt just watching!)

A little later it was that man called Vater and the little Italian Santorini found your minor duct and your nipple
And so by this time we had a good understanding of you in your nakedness
But of course, as said – you were dead

And so young Bernard explored your factories, and got a sense of your canine workings,
But you were able to hold on to your sweet secret for just a little longer
Until the Langerhans found the family jewels in the famous 2% of your population-
The islets – those beautiful eyelits – governess of all things sweet in the body

Eberle Bernard Danilevsky, and Kuhne joined up across the world to expose your antacid and enigmatic enzymatic brew
And once again your wonderful workings for a better world were exposed –
And we knew then, that you were the quiet and effective type –
A hermit who did good
But did not want the limelight

To see you as you lived and breathed in the flesh
was the mission of Wilhelm the X-Ray man
who crusaded the path to visualise 40,000 Angstroms under the skin

 

abdomen, pancreas, liver, gallbladder, kidneys, CT scan, Art in Anatomy, Ashley Davidoff MD

 

And then there was a slew of heroes who learned to slew your sickened parts – including the famous Whipple who was able to Whipple you in an inimitable way

And then a bone guy – for God’s sakes – a bone guy! – called Banting and his student Best
Exposed the insular chemistry of you insulin that had given you the power over the sweet
Never mind – in the end it was for the good of all –
And a new era was borne

And so we try to understand your form as our scans explore you as you live and breathe
And we stare in awe at your odd shape – why oh why did you choose that shape?
What are you supposed to look like? – we have no clue
And we are happy – so happy for you that you are well nourished by a double blood supply
And we wonder why you have no skin – we thought all the organs had a skin
Except for your tail – almost a foreskin

And you are off axis on two planes – what is that all about? – kinda crooked

And your twin origins and the intimacy with the duodenum, of the ventral twin
And the strange fusion of the Wirsung guy excluding the little Italian Santorini
It seems to me that your matrimonial fusion with Wirsung and the bile duct has led to more problems than the merger was worth
It does not seem in the long run, to have been a marriage made in heaven
What was that all about? Is there a grand plan to come?

 

And so we try to understand your diseases
And in some way we understand that the guy glugging down the bottle
Could be punished by your reaction
But why Oh why are you so nasty to those whose misfortune it is to have stones roll down and get no satisfaction.. down the green vile bile route
Have you not learned to live with the green secretion by now
And did you not know that by reacting the way you do, that you are cutting off your nose to spite you head?

While type 2 seems remote from you
We don’t know about this Type 1 business
Why are you made to suffer so much at the hands of your own body on your own body?
We feel sorry for you – to have your own buddies reject you – must be awful
And then to see so many young ones suffer because you don’t work
And we once again see and understand what power you control from that deep dark hermit home of yours

And the cancer thing … so silently it creeps on you causing your collagen to counter
And only making things worse as it strangles nerve, blood vessel, and your spouse duct – the green one, – without regard

And then I think of you in your prime and in your happiness
When you are with you two buddies – the splenic vein and the renal vein
And you all look so much alike, and happy swimming in that deep ocean where you hide
And I wish this was forever

 

 

Copyright 2017 Revised from previous publication in The Common Vein

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We the Cells of the Body, Want to Create a More Perfect Union

Adam and Eve Choose Cabinet Members for the Body’s Society of Cells

Arielle Davidoff and Ashley Davidoff  Copyright 2017

 Look deep into nature and then you will understand everything better – Einstein 

As Adam and Eve entered the Garden of Eden they heard the cry of the disparate cells of the body:

“Without each other we are nothing.  Please unite us in structure and function with your wisdom. E Pluribus Unum!”

E Pluribus Unum – Out of Many, One

The cells knew they would be around for a long time; their grand scheme was to pursue Oneness. They understood the consequences of bullying, selfishness, greed, and jealousy. They also knew the power of goodness, integrity, humility, and sharing.  The cells resolved to fight the evil aspects of humanity.  56 cells from all walks of life discussed the issue of collaborative community living, and drafted a constitution they all signed in Philadelphia.  The cells submitted this proposal to Adam and Eve. It read:

“We the Cells of the Body, in Order to form a more perfect Union, establish Justice, insure domestic Tranquility, provide for the common defence, promote the general Welfare, and secure the Blessings of Liberty to ourselves and our Posterity, do ordain and establish this Constitution for the United Cells of the Body.”

50 representative cells overlying the stars

Adam and Eve realized that the cell was the key “person” in their society 

Adam and Eve, taken aback by the wisdom of biology, accepted the proposal and recognized the document as a marvel of humanity.  They knew it was imperfect, but accepted that as humanity learned through time, experience, and application, it could be amended and better understood.

And so what to do now?

Adam and Eve’s first task was to choose leadership for this noble effort.  Which type of cells did the society of the body need? The stakes were high; they needed to organize an efficient society in which each of the body’s 37.2 trillion individual cells would be fed, protected, fulfilled and free.  In the Garden of Eden, Adam and Eve examined the variety of cells that surrounded them, then turned to consider the needs of society. thinking about which to choose.

Essential Functions

They debated and discussed how to build a body to house and protect its contents and enable the person to live a full and free life.  They spoke through the night and on the sixth day they arrived at a basic plan of a successful body’s most important functions. Those functions would fulfill the direction of the constitution they had drafted earlier.

Their plan was a simple list of the body’s essential functions:

  1. control, manage, direct
  2. protect and support
  3. provide food, energy, and manufacture needed products
  4. transport
  5. maintain
  6. produce and prepare the next generation

In the Garden of Eden, Adam and Eve entered the society of the cells and began to select societal leaders for the various essential functions on their list.

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Adam and Eve in the Garden of Eden’s Cell Shop

 Adam and Eve ventured into the Garden of Eden Cell Shop with their shopping list of the functional needs for their society.

Finding the Leader Cell to Control, Manage and Direct

The cell to govern the body would need an overview of the whole situation of life and Oneness.  Its chief characteristics would be wisdom, honesty, humility and integrity. It also needed to sense and react appropriately to both the external and internal environment so that everybody could live a safe and fulfilling life. This cell also had to be able to communicate with every cell in the body – all 37.2 trillion of them – from the tip of the head to the tips of the toes.

cells-0022-catalogue-signed

The Neuron – “Il Presidente”

They chose the brain cell or neuron for its leadership, and they playfully called  it “Il Presidente.”  Crucially, the neuron could connect not only with other brain cells, but also (directly or indirectly) with every cell in the body. The neuron could also react to the outside environment.

Adam and Eve Trying on the Brain Cell for Size

 Adam tried on the brain cell and sought Eve’s approval.  It was tailored for both the internal and external environments.

Modified public domain work of Henri Rousseau “The Dream”  1910 (MoMA)

“Il presidente” made his first speech referencing Hillel’s sage advice: “If I am not for the body of my person who will be?  And if I am only for the body of my person, then what am I?  If not now when then?”

Adam and Eve nodded at each other, satisfied with their choice.

Finding a Cell for Protection  

Adam and Eve lived in a dangerous environment.  Wild, predatory animals ranged in size from the dinosaurs to violent religious zealots, to the smallest virus particles.  They identified two principal needs – protection from the outside, and protection from the inside of the body.  They turned first to secure internal security.

Adam and Eve were aware of Voltaire’s wise words: “Beware of the words ‘internal security,’ for they are the eternal cry of the oppressor.”  They also knew, conversely, that Cicero stated “Salus populi suprema lex esto”  –  “Let the good (or safety) of the people be the supreme (or highest) law.”

The cell responsible for internal environmental control had to be highly intelligent, so it could sensitively identify the enemy without racial profiling.  Adam and Eve searched for a long time before they encountered an amazing, introverted cell genius, decorated with Einstein’s hairstyle. They called it the macrophage.  This cell had an exquisite memory for detail and an uncanny ability to spot and destroy the enemy of peace.  Rebels and terrorists in the body were no match for this cell.

 

The Macrophage Police Cell with a Crazy Hairstyle

The macrophage’s motto was the simple equation:   E = mc2

Enemy of the Common Good will be taken down by the Macrophage with Great Conviction for the sake of the peace of humanity

Finding a Cell to Manufacture Food, Energy, and Other Needed Products

The manufacturing function related to internal economy.  Adam and Eve knew that a successful internal economy required self sufficiency. All able bodied cells had a right and an obligation to work.  Adam and Eve remembered and appreciated the wise words of the famous John Kennedy who declared “My fellow Americans, ask not what your country can do for you, ask what you can do for your country.”

The body would need manufacturing facilities present in all of its parts.  Noticing, however, that the liver cell proved especially adept at manufacturing, Adam and Eve chose this cell to lead the body’s internal economy.

The Liver Cell – Key in Metabolic Function in the Metabolic Warehouse of the Body

 

Finding a Cell to Lead the Transport Function

Transport to and from the cells would be an essential bodily function.  Adam and Eve chose the red cell to lead the effort, since it could transport oxygen and carbon dioxide, which they knew is vital to life.  The red cell with its colorful hemoglobin was a natural choice.  They recognized its ability to rapidly exchange gases in the lungs and at the cell as a stunning accomplishment of nature.

Red Cell with Hemoglobin Responsible for the Transport of Oxygen and Carbon Dioxide

Finding the Cell to Lead Maintenance: Repair, Cleaning and Waste Removal 

 cells-0026-catalogue-signed

Stem Cell Maintenance and Repair

The stem cell can magically transform into many different types of cells necessary to repair and regenerate tissues, which can wear over time. Timed cell death, or apoptosis, is natural and regeneration is necessary. The adult stem cell is responsible for regeneration of blood cells, endothelia of blood vessels, and epithelia of skin, intestine, and respiratory tract.  Adult stem cells also repair tissues such as bone, cartilage, and non-cardiac muscle, which are prone to injury due to physical activity.  Adam and Eve chose the multipotential adult stem cell to maintain the body’s cell populations.

Preparation for the Next Generation 

The miracle of creation understood the importance of education.  Each generation would advance to wholeness only if it learned from the experience of prior generations.  Humanity has preserved history in archives, museums, and libraries.  Similarly, within the nucleus of each cell lies the accumulated experience of the generations in the library of the DNA.  Every cell contains all this valuable information, which continues to evolve as human experience advances.

The Library of Accumulated Experience in the Nucleus of the Cell
Courtesy of photograph provided by Ralf Roletschek / fahrradmonteur.de subsequently modified 

Best for Last: Reproduction

Nature drives men and woman together with the most pleasurable and profound experience to enable e plurabus unum of the female egg and male sperm.  The mechanical union is infused with a miraculous spark of life that enables the continuation of the species.
Sperm and Egg Meet and a Miracle (not to be taken for granted) Occurs
Adam and Eve rested, exhausted in each other arms, assured that the wonderful human experiment had begun.

And the next day…

…there was a meeting of the minds on the palace lawn.

 7 Cabinet Ministers Posing in Front of Government Center

The 7 cells chosen by Adam and Eve to  to advise the design of the structure and function of the body.

From left to right; Liver cell (manufacture), Macrophage (defense and protection) Ovum (reproduction) Neuron (government) Sperm (reproduction) Stem cell (maintenance and repair) and Red cell (transport)

 

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Adam and Eve: foundations of human biology

Essentials of Human Biology: 

The Story of Adam and Eve as they lay the foundations of humanity

Adam and Eve

Adam and Eve were the forerunners of human biology, who were charged with building society and humanity. They began with nothing but their common sense, human instincts, and a vision for the perfect person and community.

cells-0041-catalogue-signed

As they stood observing the wonder of sunset and the ocean, they pondered the prediction that their seed would be multiplied as greatly as the stars of the heavens, and the sands on the shore.  This idea seemed unfathomable. They knew, however, that humanity needed a solid foundation.

From these early beginnings, they understood the most basic principles of life. The desired end was fulfillment of the physical, mental and spiritual needs of both the individual and the community. Their task was to design a template with universal application, one that could stand the test of time.

For the physical aspect they knew:

     1) Structure and Function were the basic elements of biology and life.

     2) Structure was made of parts.

structure-0002-catalogue-signed

     3) Function consisted of 3 vital abilities: receive, process, and export.

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     4) Collaboration was essential, between:

          structure and structure, function and function, and structure and function

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     For the mental life, they knew essential elements were more abstract and included abilities in:

         sensory function

         memory

         thought

         judgment

         expressive function  

For the spiritual life:

the ultimate goal was to achieve Oneness, which conceptually was the most abstract and difficult to achieve.

Space and Time

Adam and Eve dealt with the physical constraints of space and time.  They understood that unlike space, time was progressive.  Time influenced both the individual life as well as the life of the species in perpetuity.

They knew the evolution of an entire species would require a long, almost indefinite amount of time. Since an individual life is relatively short, growth and especially reproduction in a single life cycle would be essential. Only a miracle could answer the challenge of creating a new life, and this miracle, unlike evolution, would be urgently necessary. Adam and Eve therefore turned to their Creator, and begged for this miracle as an immediate need.